British artificial intelligence giant DeepMind has released a database of nearly all human protein structures that it amassed as part of its AlphaFold program. Last year, the organisers of the biennial Critical Assessment of protein Structure Prediction (CASP) recognised AlphaFold as a solution to the grand challenge of figuring out what shapes proteins fold into. "We have been stuck on this one problem – how do proteins fold up – for nearly 50 years. To see DeepMind produce a solution for this, having worked personally on this problem for so long and after so many stops and starts, wondering if we'd ever get there, is a very special moment." AlphaFold is a major scientific advance that will play a crucial role in helping scientists to solve important problems such as the protein misfolding associated with diseases such as Alzheimer's, Parkinson's, cystic fibrosis and Huntington's disease.